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MUHAMMAD IHSAN UDIN, 051311133143

(2017)

AKTIVITAS ANTI HEPATITIS C FRAKSI SPONS Microxina subtilis DAN IDENTIFIKASI SENYAWA DALAM FRAKSI AKTIF.

Skripsi thesis, Universitas Airlangga.

Summary

The results of preliminary examine indicated that ethyl acetate extract
of Microxina subtilis sponge had potential antivirus exercise on hepatitis C
virus with IC50 worth of 40.50 μg/mL. On this examine, the fraction of ethyl
acetate extract of M. subtilis was examined towards hepatitis C JFH1 virus on
hepatocyte cell tradition Huh7it. The antiviral exercise was assessed based mostly on
the worth of share of inhibition by evaluating the distinction between
the variety of contaminated cells on the management and the variety of contaminated cells
on the detrimental management. The consequence indicated that based mostly on the focus
of 100 μg/mL, there have been three fractions obtained from the entire of seven fractions,
particularly fractions quantity 5, 6 and seven which confirmed inhibition exercise with
% worth of 36.eight ± three.three %; 89.2 ± 7.four % and 80.7 ± eight.7% respectively, whereas
the opposite four fractions had no inhibition exercise. Fraction quantity 6 and seven
which had % inhibition of greater than 50% had been recognized to find the
compounds contained. The compounds had been anticipated to had position on
antivirus exercise. The evaluation of compound utilizing 1H NMR spectroscopy
confirmed that each fraction had the identical essential compound, particularly fatty acid
teams. Fraction 7 was recognized with the mixture of fuel
chromatography (GC) and mass spectroscopy. The evaluation outcomes utilizing
GC-MS indicated that the fatty acid group compounds had been hexadecanoic
acid; heptadecanoic acid; 9,12,15-octadecatrieonicacid; octadecanoid acid;
eicosanoic acid and eight,11-octadecadienoic acid.

Merchandise Kind: Thesis

(Skripsi)

Extra Info: KKB KK2 FF.FT.44/17 Udi a
Uncontrolled Key phrases: Antivirus, HCV, marine sponge, Microxina subtilis, GC-MS, 1H NMR, fatty acid
Topics: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
Creators E-mail
MUHAMMAD IHSAN UDIN, 051311133143 UNSPECIFIED
Contributors:
Contribution Title E-mail
Contributor Achmad Fuad Hafid, Dr., M.S., Apt., UNSPECIFIED
Contributor Suciati, S.Si., M.Phil, Ph.D, Apt. UNSPECIFIED
Depositing Consumer:

Mr Binkol1 1

Date Deposited: 28 Dec 2017 19:15
Final Modified: 17 Jan 2018 20:50
URI: http://repository.unair.ac.id/id/eprint/65214
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