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DIO LUTFI WIDIANTO, 051311133194

(2017)

BIOAVAILABILITAS DISPERSI PADAT QUERCETIN-HPMC PADA KELINCI.

Skripsi thesis, Universitas Airlangga.

Summary

Quercetin belongs to the Biopharmaceutics Classification
System (BCS) II, subsequently modifying the quercetin formulation will
have an effect on the bioavailability. On this examine, quercetin was modified by including
HPMC to the quercetin as stabilizer of amorphous type of quercetin strong
dispersion system. The bioavailability profile of the 250mg/kg doses of
quercetin was investigated in 6 rabbits. Quercetin was administered underneath
two situation : single quercetin as management and strong dispersion quercetin-
HPMC. The focus of quercetin in plasma have been decided by a
validated excessive efficiency liquid chrmatography methodology. Bioavailability
parameters together with Tmax, Cmax and AUC0-480 have been decided. In management
group, the common worth of Tmax, Cmax, AUC0-480 have been 30 min, and zero.40 ±
zero.23 g/mL, 44.40 ± 39.42 g.minutes/mL, respectively Tmax, Cmax and
AUC0-480 of quercetin after the administration of strong dispersion have been 15
min, zero.44 ± zero.23 g/mL, 52.46 ± 35.96 g.minutes/mL respectively
there was slight, however not important enhance in Cmax and AUC0-480 after
administration of quercetin-HPMC as in comparison with quercetin alone. It may
be concluded that HPMC can speed up Tmax however not change the
bioavailability of quercetin confirmed by Cmax and AUC0-480.

Merchandise Kind: Thesis

(Skripsi)

Extra Info: KKB KK2 FF.FK.49/17 Wid b
Uncontrolled Key phrases: Quercetin, HPMC, strong dispersion, bioavailability, HPLC
Topics: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
Creators E-mail
DIO LUTFI WIDIANTO, 051311133194 UNSPECIFIED
Contributors:
Contribution Identify E-mail
Contributor Mahardian Rahmadi, S.Si., M.Sc., Ph.D., Apt UNSPECIFIED
Contributor Chrismawan Ardianto, S.Farm., M.Sc., Ph.D., Apt UNSPECIFIED
Depositing Consumer:

Mr Binkol2 2

Date Deposited: 26 Dec 2017 22:47
Final Modified: 26 Dec 2017 22:47
URI: http://repository.unair.ac.id/id/eprint/65457
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