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Skripsi farmasi dengan judul ” PENGARUH KADAR POLYPLASDONE XL-10 TERHADAP KARAKTERISTIK CO-PROCESSED EXCIPIENT MANITOL � POLYPLASDONE XL-10 – GELATIN UNTUK ORALLY DISINTEGRATING TABLET( Dibuat Dengan Metode Fluid-Mattress Granulation ) Repository c” ini bisa Kamu download disini, dan masih banyak skripsi ter-baru lainnya.

MULYADI NUR AINI, 050911166

(2013)

PENGARUH KADAR POLYPLASDONE XL-10 TERHADAP KARAKTERISTIK CO-PROCESSED EXCIPIENT MANITOL � POLYPLASDONE XL-10 – GELATIN UNTUK ORALLY DISINTEGRATING TABLET( Dibuat Dengan Metode Fluid-Mattress Granulation ).

Skripsi thesis, UNIVERSITAS AIRLANGGA.

Summary

There’s a robust pattern within the pharmaceutical trade towards growing Orally Disintegrating Tablets (ODTs), as a result of they’ve varied advantages for the affected person in contrast with common tablets. ODTs disintegrate quickly within the mouth with none water, often in a matter of seconds. Within the current analysis, co-processed excipients for Orally Disintegrating Tablets (ODTs) had been designed with a view to develop ODT by direct compression technique.
Granules of co-processed excipients had been produced by Fluid Mattress Granulation technique, containing mannitol as filler and sweetener, Polyplasdone XL-10 as superdisintegrant in two completely different concentrations: 5% and 10%, and gelatin as binder in 2% focus.
The traits of the granules had been evaluated together with moisture content material, particle-size distribution, density, movement fee, angle of repose, % compressibility, compactibility, disintegrating time, dilution potential, and Scanning Electron Microscope (SEM).
The consequence was analyzed by SPSS 20 statistic programme utilizing Impartial Two Pattern t-test. Statistical evaluation confirmed that there was a big distinction on traits amongst formulation, besides the compactibility. It may be concluded that the optimal components was the components with 10% of Polyplasdone XL-10, with movement fee of 10,11 g/s, compactibility and disintegrating time within the pressure of 1 ton of 12,80 kP and 60,19 second, and dilution potential within the ratio of 50 : 50 co-processed excipient : paracetamol of 5,44 kP.

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