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Tesis farmasi yang berjudul ” ANALISIS PENGARUH PEMBERIAN SIMVASTATIN TERHADAP KADAR SERUM HMGB1 PADA PASIEN STROKE ISKEMIK AKUT (Riset dilakukan di IRNA Medik SMF Ilmu Penyakit Saraf RSUD Dr. Soetomo dan RS Universitas Airlangga Surabaya) Repository c” berikut bisa Kamu download disini, dan masih banyak skripsi ter-baru lainnya.

Fortunate Argasetya, S.Farm., Apt, 051515153030

(2018)

ANALISIS PENGARUH PEMBERIAN SIMVASTATIN TERHADAP KADAR SERUM HMGB1 PADA PASIEN STROKE ISKEMIK AKUT (Riset dilakukan di IRNA Medik SMF Ilmu Penyakit Saraf RSUD Dr. Soetomo dan RS Universitas Airlangga Surabaya).

Thesis thesis, Universitas Airlangga.

Summary

Background : In ischemic stroke, cerebral artery occlusion results in nutrient and oxygen
depletion, in addition to necrosis and subsequent irritation in neural tissue. The injured mind
cells launch danger-associated molecular patterns (DAMPs) that induce or escalate
irritation. These DAMPs embody high-mobility group box-1 (HMGB1). Pleotropic
impact of simvastatin as antiinflammatory is one among HMGB1 goal drug. There are few
research exhibiting the medical associations between HMGB1 and simvastatin as
antiinflammatory in ischemic stroke. Right here, we decided the medical significance of
simvastatin with serum HMGB1 ranges in sufferers with acute ischemic stroke.
Goal : The goal of this potential observational research is to investigate the impact of
simvastatin 20 mg on serum HMGB1 ranges in acute ischemic stroke sufferers as
antiinflammatory course of.
Technique : We enrolled 44 sufferers (28 males; 16 ladies; imply age: 60.zero years) over three months.
Pattern had been collected by easy random sampling from August – November 2017. The
serum HMGB1 ranges had been measured on acute ischemic stroke sufferers whom given
simvastatin 20 mg or placebo for five days in inpatient ward. Blood collected on admission day
1 (pre intervention) and day 5 (publish intervention). After centrifugation, serum samples had been
saved at -80°C earlier than measurement. We used an ELISA Equipment (IBL Worldwide) to find out
HMGB1 concentrations. Protocol of this research had been reviewed by Moral Committee Dr.
Soetomo Common Hospital and Universitas Airlangga Hospital Surabaya.
Outcome : Serum HMGB1 ranges in ischemic stroke sufferers had been elevated in placebo group
and decreased in simvastatin group after intervention for five days, not considerably each
(p=zero.861 and zero.267). HMGB1 ranges didn’t considerably differ between two teams after
interventions for five days (p=zero.222).
Conclusion : Simvastatin 20 mg decreased HMGB1 ranges not considerably in acute ischemic
stroke sufferers after given for five days admission and never considerably differ between two
group after interventions.

Merchandise Kind: Thesis

(Thesis)

Extra Data: KKB KK-2 TFK.06/18 Arg a
Uncontrolled Key phrases: Ischemic stroke, Simvastatin, HMGB1, Inflammatory marker, DAMPs
Topics: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
Creators E-mail
Fortunate Argasetya, S.Farm., Apt, 051515153030 UNSPECIFIED
Contributors:
Contribution Identify E-mail
Contributor Didik Hasmono, Drs. , MS., Apt UNSPECIFIED
Contributor Abdulloh Machin, dr., Sp.S UNSPECIFIED
Depositing Person:

sugiati

Date Deposited: 08 Mar 2018 20:08
Final Modified: 08 Mar 2018 20:08
URI: http://repository.unair.ac.id/id/eprint/70516
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