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RIKY REBECHA, 051515153020
ANALISIS PERUBAHAN KADAR IFN-γ DAN IL-6 SEBAGAI PENANDA INFLAMASI DAN RESPONS TERAPI OBAT ANTI TUBERKULOSIS PASIEN TB PARU MDR (Riset dilakukan di Poli TB MDR RSUD Dr. Soetomo Surabaya).
Thesis thesis, UNIVERSITAS AIRLANGGA.
Background : MDR TB is an infectious illness attributable to Mycobacterium tuberculosis
that’s proof against isoniazid and rifampicin, with or with out first-line antituberculosis. The
commonplace for monitoring the efficacy of antituberculosis drug for MDR TB use microscopic
evaluation of of Acid-fast bacilli (AFB) from sputum throughout therapy interval. Cough isn’t
dominant symptom in MDR TB sufferers and the sputum that’s produced barely within the
morning. That is fairly tough on microscopic evaluation of AFB, in order that required different
biomarker help to evaluate the situation of systemic irritation attributable to
Mycobacterium tuberculosis. IFN-γ and IL-6 are proinflammatory cytokines stimulated by
Th1 cells when macrophages are contaminated with Mycobacterium tuberculosis. These
markers can be utilized to in MDR TB.
Goal : The goal of this research was to research the serum ranges of IFN-γ and IL-6
bomarkers as inflammatory brokers and to research the correlation medical parameters
in response to Bandim TB Rating technique.
Technique : This research was an analytical observational technique with cross sectional design.
Knowledge was collected from July to December 2017 interval and had been authorised by Moral
Committee of Dr. Soetomo Educating Hospital Surabaya. Sufferers who met the inclusion
standards was incluced in 4 group sufferers primarily based on the period of MDR-TB regiments.
Samples was analyzed through the use of enzyme-linked immunosorbent assay (ELISA) technique
earlier than (pre) and after four weeks (put up).
Outcome : On this research, 29 sufferers had been included in to the 4 research group primarily based on
totally different size of remedy. There was a rise of IFN-γ ranges in group 1 (46.77
pg/ml±100.23), a lower in group 2 (147 pg/ml±166.61), a lower in group three (41.55
pg/ml±103.59) and a rise in group four (9 pg/ml±189.58). There was a rise of IL-6
ranges in group 1 (21.34 pg/ml±217.93), a lower in group 2 (230.37 pg/ml±64.36), a
lower in group three (116.85 pg/ml±367.44) and a rise in group four (42.07
Conclusion : The outcomes confirmed that the serum ranges of IFN-γ and IL-6 markers in 4
group sufferers who acquired MDR TB regimens after 4 weeks weren’t been modified
considerably (p>zero.05). Each of which had been supported by Bandim TB Rating of 89.66 %
sufferers that indicated the inflammatory development.
|Further Data:||KKB KK-2 TFK. 18-18 Reb a|
|Uncontrolled Key phrases:||Interferon-gamma, Interleukin-6, Multidrug-Resistant Tuberculosis, MDR TB regimens, Bandim TB Rating, Inflamation Biomarker.|
|Topics:||R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||05. Fakultas Farmasi > Farmasi Klinis|
|Date Deposited:||11 Mar 2018 16:48|
|Final Modified:||11 Mar 2018 16:48|
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