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Vita Rahmayani, 051415153012
HUBUNGAN ANTARA KADAR SERUM hs_CRP, HEPCIDIN DAN STATUS BESI DENGAN CAPAIAN HEMOGLOBIN PADA PASIEN PENYAKIT GINJAL KRONIS YANG MENJALANI HEMODIALISIS DAN MENDAPATKAN TERAPI ERITROPOETIN.
Thesis thesis, UNIVERSITAS AIRLANGGA.
Background: Power kidney illness (CKD) is an irregular situation of each kidney
operate and construction inside greater than three months that provides demaged impact to the
well being. One of many kindey complication is an anemia. It pertains to discount of eritrophoetin
(EPO) produced by kidney. Due to this fact, this anemia wants EPO theraphy. Generally, EPO
theraphy is just not at all times successfull as a result of physique lack of iron throughout inflammational
situation. This thypically case is known as as EPO resistance. As well as, iron is amassed
within the type of ferritin. The buildup is inhibited by ferroportine, an iron transporter
inhibitor that’s probably degraded by hepcidin regulation mechanism. Because the iron
metabolism is regulated tightly by hepcidin hormone that will increase throughout irritation.
Goals: To investigate correlations between serum hepcidin, hs-CRP and iron ranges with
serum heamoglobin degree goal in CKD with hemodialysis sufferers and EPO remedy.
Metode: That was an observational cross-sectional analysis utilizing 23 consecutive pattern
of CKD sufferers who had been doing each hemodialysis and EPO remedy in Adi Husada
Undaan Wetan Hospital Surabaya. On this analysis we measured the hepsidin-25 degree by
ELISA and serum degree through the use of automated ferritin based mostly on CMIA. The ultimate knowledge had been
analysed within the important correlation vary < zero,05.
Outcomes: 23 samples had been obtained which met the inclusion and exclusion standards after which
carried out anaylisis of correlation take a look at.The outcome exhibits Within the multivariable analyses of the
linear regression mannequin, there weren’t important correlations between hepcidin, hs-CRP
and iron standing (ferritin and Transferrin Saturation) ranges with haemoglobin ranges goal
(p<zero.05). Within the bivariate analyses correlation, there was not a considerably correlated
between hs-CRP with hepcidin ranges within the serum (p>zero,05), there was a considerably
correlated between hepcidin with ferritine ranges within the serum (P= zero,002 and R=zero,604), was
not a considerably correlated between ferritin with transfterrin saturation ranges within the
serum (p>zero,05) and was not a considerably correlated between transfterrin saturation ranges
with haemoglobin ranges within the serum (p>zero,05).
Conclusion: There weren’t important correlation between serum hepcidin, hs-CRP and
iron ranges with serum heamoglobin degree goal in CKD with hemodialysis sufferers and
|Further Info:||KKB KK-2 TFK. 22-18 Rah h|
|Uncontrolled Key phrases:||Hepcidin, hs-CRP, iron standing, heamoglobin, hemodialysis, eritropoetin.|
|Topics:||R Medicine > RC Internal medicine > RC31-1245 Internal medicine
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||05. Fakultas Farmasi > Farmasi Klinis|
|Date Deposited:||11 Mar 2018 16:12|
|Final Modified:||11 Mar 2018 16:12|
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