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Tesis farmasi yang berjudul ” PENGARUH PEMBERIAN SIMVASTATIN TERHADAP KADAR SERUM INTERLEUKIN-1 BETA (IL-1β) PADA PASIEN STROKE ISKEMIK AKUT (Riset dilakukan di IRNA Medik Ilmu Penyakit Saraf RSUD Dr. Soetomo Surabaya dan Rumah Sakit Universitas Airlangga Surabaya) Repository c” ini bisa Kamu unduh disini, dan masih banyak skripsi ter-baru lainnya.

AYU VISITA DEWI, 051515153031

(2017)

PENGARUH PEMBERIAN SIMVASTATIN TERHADAP KADAR SERUM INTERLEUKIN-1 BETA (IL-1β) PADA PASIEN STROKE ISKEMIK AKUT (Riset dilakukan di IRNA Medik Ilmu Penyakit Saraf RSUD Dr. Soetomo Surabaya dan Rumah Sakit Universitas Airlangga Surabaya).

Thesis thesis, UNIVERSITAS AIRLANGGA.

Summary

Background : Ischemic stroke is a focal neurological dysfunction that happens on account of
inadequate or disconnected blood circulation to the lokasi of the mind, often attributable to clogged
arteries. The sudden blockage of blood circulation to the mind causes tissue hypoxia and triggers
an inflammatory cascade resulting in impairment of ion homeostasis, neuronal
excitotoxicity, intracellular calcium overload, free radical era, and lipid
peroxidation which is able to trigger neuronal damage. IL-1β is likely one of the essential inflammatory
mediators within the excitotoxicity of vascular ischemic processes and it has necessary function in
cell harm and demise in ischemic stroke. Within the earlier research, Simvastatin, when
administered inside 24 hours of the acute ischemic stroke onset, can inhibit the rise in
IL-1β serum ranges.
Targets : To research the distinction of IL-1β serum ranges between the group of acute
ischemic stroke sufferers handled with Simvastatin 20 mg and the ischemic stroke sufferers in
placebo group.
Methodology : This research is randomized managed trial. Information have been collected between August
and November 2017. Venous blood pattern have been obtained to extract IL-1β serum degree
earlier than and after 5 days of intervention. Moral Committee of Dr Soetomo Educating
Hospital Surabaya and Airlangga College Hospital Surabaya accredited protocol of this
research. The knowledgeable consents should be signed as a proof of participation on this research. The
measured information of IL-1β serum degree have been analyzed utilizing Mann Whitney take a look at to check
non parametric information between Simvastatin and placebo group and utilizing Wilcoxon take a look at to
examine non parametric information inside group.
Consequence : Whole 44 members have been embrace on this research, divided into 22 sufferers in placebo
group and 22 sufferers in Simvastatin group. Affected person traits between two teams
weren’t considerably totally different (p > zero.05). The imply of IL-1β serum ranges earlier than
intervention between placebo group (60.909 ± 20.288 pg/mL) and Simvastatin group
(41.846 ± 24.875 pg/mL) weren’t considerably totally different (p > zero.05). The imply of IL-1β
serum ranges after intervention between placebo group (40.821 ± 11.903 pg/mL) and
Simvastatin group (30.748 ± 22.303 pg/mL) weren’t considerably totally different (p > zero.05).
The imply of IL-1β serum degree in placebo group lower with p > zero.05, whereas in
Simvastatin group the imply of IL-1β serum lower with p > zero.05
Conclusion : 5 days administration of Simvastatin 20 mg couldn’t lower the IL-1β
serum degree in acute ischemic stroke in contrast with placebo group.

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